- A patient taking warfarin has started a new medication, amiodarone. What effect might this interaction have on the patient?
- A. Increased risk of bleeding
- B. Decreased therapeutic effect of warfarin
- C. Increased clotting tendency
- D. No significant interaction
- Which of the following should a nurse monitor when a patient is prescribed lithium and begins taking furosemide?
- A. Hyperkalemia
- B. Lithium toxicity
- C. Dehydration
- D. Hypertension
- What is the effect of combining a beta-blocker like metoprolol with insulin in a diabetic patient?
- A. Increased blood glucose levels
- B. Risk of masked hypoglycemia symptoms
- C. Risk of ketoacidosis
- D. No interaction
- When a patient is prescribed both digoxin and verapamil, the nurse should monitor for:
- A. Bradycardia
- B. Hyperkalemia
- C. Increased diuresis
- D. Hypertension
- What happens when a patient taking simvastatin is prescribed clarithromycin?
- A. Decreased statin efficacy
- B. Increased risk of myopathy or rhabdomyolysis
- C. No significant interaction
- D. Decreased cholesterol levels
SATA (Select All That Apply) Questions
- A nurse is educating a patient on drug interactions with grapefruit juice. Which medications might interact negatively with grapefruit juice? (Select all that apply)
- A. Atorvastatin
- B. Amoxicillin
- C. Cyclosporine
- D. Nifedipine
- E. Metformin
- Which combinations increase the risk of serotonin syndrome? (Select all that apply)
- A. SSRIs with MAOIs
- B. Tricyclic antidepressants with St. John’s Wort
- C. Furosemide with digoxin
- D. Opioids like tramadol with SSRIs
- E. Beta-blockers with ACE inhibitors
Scenario-Based Questions
- A 65-year-old male taking nitrates for angina is prescribed sildenafil for erectile dysfunction. What is the priority nursing action?
- A. Administer the sildenafil as prescribed.
- B. Assess the patient’s blood pressure before administration.
- C. Hold the sildenafil and notify the healthcare provider.
- D. Educate the patient about potential gastrointestinal side effects.
- A patient taking phenytoin for epilepsy begins oral contraceptives. The nurse should:
- A. Advise the patient that the medications will not interact.
- B. Suggest using an additional form of contraception.
- C. Monitor for signs of phenytoin toxicity.
- D. Encourage the patient to take the medications with food.
- A patient taking levothyroxine for hypothyroidism starts taking calcium supplements. What instructions should the nurse provide?
- A. Take both medications together with meals.
- B. Separate the medications by at least 4 hours.
- C. Discontinue the calcium supplements.
- D. Increase the levothyroxine dose to counteract the interaction.
Advanced Application Questions
- What is the primary concern when a patient on potassium-sparing diuretics is prescribed ACE inhibitors?
- A. Hypokalemia
- B. Hyperkalemia
- C. Hyponatremia
- D. Hypercalcemia
- A patient is prescribed fluoroquinolone antibiotics while also taking antacids. What should the nurse instruct the patient?
- A. Take both medications together for better absorption.
- B. Avoid antacids for at least 2 hours before and after the antibiotic.
- C. Increase water intake to prevent kidney stones.
- D. Take the antacids only at bedtime.
- What should a nurse monitor when a patient is taking both theophylline and ciprofloxacin?
- A. Increased theophylline levels and potential toxicity
- B. Decreased therapeutic effect of ciprofloxacin
- C. Enhanced clearance of both drugs
- D. Risk of severe hypertension
Knowledge Recall Questions
- Which drug interaction is most likely when a patient taking NSAIDs is prescribed a diuretic like furosemide?
- A. Decreased efficacy of furosemide
- B. Increased risk of gastrointestinal bleeding
- C. Risk of hypokalemia
- D. No interaction
- What happens if a patient takes aspirin and clopidogrel together?
- A. Decreased risk of clotting
- B. Increased risk of bleeding
- C. Enhanced platelet aggregation
- D. No significant interaction