Construct a 2×2 table using relevant figures shown in the abstract, and answer the following questions: [4 marks]
(i) What is the risk of losing at least 5% of body weight in all patients included in the study?
(ii) What is the risk of losing at least 5% of body weight in patients who were treated with liraglutide?
(iii) What is the risk of losing at least 5% of body weight in patients who were treated with placebo?
(iv) What is the relative risk of treatment with liraglutide verus placebo with regard to weight management? How would you interpret this relative risk estimate?
Q6b. If equal numbers of patients in the population were treated with liraglutide vs placebo treatment, what would be the expected population relative risk reduction (RRR) for liraglutide treatment? How would you interpret this measure? [4 marks]
Q6c. How many patients need to be treated with liraglutide for one more patient to benefit compared with the placebo? What is this measure called? How would you interpret this measure [4 marks]?
Q6d. How does the measure in question 5b differ from question 5c? [4 marks]
Read the attached original research article (Khorana et al., 2019), available in vUWS), and now answer Questions 7 to 9:
Q7. What characteristics of the study would you consider in order to determine if its findings are valid? Include wider considerations of study quality/validity and give examples. (Q8 will address relevance, and the next question will ask how to determine the importance of the findings…for this question, focus on the internal validity of the study) [8 marks]
Q8. What characteristics of the findings would you consider, in order, to determine if they are clinically meaningful and statistically significant? Include examples. (You’ve already addressed validity…for this question, focus on how to determine the clinical significance and statistical significance of an effect reported in the study) [8 marks]
Q9. What characteristics of the study would you consider, in order, to determine if it is generalizable to your context? Explain your answers and provide examples. (Questions 6 and 7 have asked how to determine if the study is valid, and how important the findings are….for this question, focus on how to determine if it is really relevant or generalizable to your practice.) [8 marks]
0 Please do not list the characteristics in questions 8–10, but explain your answers succinctly.
0 You can also download the article from the University Library using your student login details.
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